Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.
Scharton et al, J. Exp. Med. August 1993.
Publications Tag: Preclinical
The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.
Afonso et al, Science, January 1994.
IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.
Scharton et al, J Immunol, May 1995
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
Gazzinelli et al, J Immunol, July 1996
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.
Scharton et al, J Immunol, November 1996
Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response
Hondowicz et al, J Immunol, November 1997
Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii.
Yap et al, Infect Immun, September 1998
Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge
Glenn et al, J Immunol, October 1998
Transcutaneous immunization using colonization factor and heat-labile enterotoxin induces correlates of protective immunity for enterotoxigenic Escherichia coli.
Yu et al, Infect Immun, March 2002
Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants.
Scharton et al, Infect Immun, September 2000